Born in Tamale, Wakaso began his senior career in Ashanti Gold SC. In 2008 he moved abroad and signed with Elche CF in Spain on a five-year contract, but only joined the club nearly two months later however due to international duty.
In late January 2011, after several bouts of indiscipline and club internal codes violations, Wakaso was released by the Valencian Community club. Shortly after he joined another side in the region and Segunda División, Villarreal CF’s B-team.
On 27 February 2011 Wakaso made his La Liga debut, replacing José Catalá in the last minutes of a 2–2 away draw against Racing de Santander. He only played six games in his first full season and the Yellow Submarine was also relegated, after twelve years in the top flight.
Wakaso signed for RCD Espanyol on 11 July 2012, penning a four-year contract. He started in 23 of his league appearances for the Catalans in his first and only season.